Research program
Circadian Biology • Systems Biology • Circadian Medicine
The Hogenesch Lab studies biological timing across molecular mechanisms, genome-scale transcription, and medicine. The work links core clock architecture to tissue-scale rhythmic programs and to translational questions about when physiology, disease processes, and therapies are most sensitive to time of day.
Affiliations
Hughes et al., PLoS Genetics 2009. Open-access figure.
Nobel Context
Awarded for discoveries of molecular mechanisms controlling the circadian rhythm. The lab’s clock work lives in that scientific arc.
Awarded for discoveries of how cells sense and adapt to oxygen availability. The official Nobel historical account also names Hogenesch et al., 1997 in the HIF-2alpha story.
Aziz Sancar shared the prize for mechanistic studies of DNA repair. Aziz is a friend and colleague, and part of the lab’s broader scientific orbit.
Contributions
Research Themes
Mechanistic work on BMAL1, NPAS2, transcriptional feedback architecture, and clock-controlled gene regulation in mammalian systems.
Rhythmic physiology across organs, tissues, and cell systems, including the architecture and outputs of biological clocks.
Genome-scale transcriptional programs, the mammalian circadian transcriptome, and atlas-level studies of time across tissues.
Algorithms and public tools including JTK_CYCLE, PSEA, MetaCycle, CYCLOPS, CYCLOPS2, CircaDB, and Gene Atlas.
Human transcriptomics, chronotherapy, and published work linking circadian phenotypes to Human Genetics and rare disease, including Smith-Kingsmore syndrome.
Featured Resource
CircaDB is a public database of mammalian circadian gene expression profiles developed by the Hogenesch Lab in collaboration with Andrew Su. The resource allows researchers to explore rhythmic gene expression across tissues and datasets and has become a widely used tool in the circadian biology community.
Pizarro et al., Nucleic Acids Research 2013. Open-access figure (CC BY-NC 3.0).
People
John B. Hogenesch, PhD
Thomas F. Boat Chair, Cincinnati Children’s Hospital Medical Center.
The lab’s work spans molecular circadian biology, systems biology, public resources, and translational questions in circadian medicine.
Research in the group brings together experimental biologists, computational scientists, clinician-scientists, trainees, and collaborators around shared questions of biological timing.
Press
Selected external coverage of the lab’s published work, with links to stories and associated figure or image pages.